[Immune System] The Single System In Charge of Building Muscle, Losing Fat, and Reducing Stress w/ Anders Varner, Doug Larson, Coach Travis Mash and Dan Garner Barbell Shrugged #634

lorem ipsumShrug family, this week on Barbell Shrug, we are talking about the single system that is going to help you build more muscle, lose more fat, and reduce more stress in your life so you can get better results in the gym and hit your goals faster.

We're talking about your immune system today. We're talking about the external and internal stressors that show up in your lab work, in testing, and all of the things that are on the inside, the hidden stressors, as well as the external stressors, like your work, your life, your kids, your lack of sleep, and how all that affects your immune system, which is robbing you of the gains that you are working so hard for inside the gym.

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Friends, let's get into the show. Welcome to Barbell Shrug! I'm Anders Warner, Doug Larson, Coach Travis Mast, Dan Garner, today on Barbell Shrug, we're digging into the immune system.

And if there's anything that's like the hottest topic of all of the people around the world for the last two years, it's your immune system.

Like this cool new term that I'd never heard until two years ago, immunocompromised. Right, that's a real word now.

That's a real word, everybody knows. Everybody has an opinion on it. Nobody knows what the hell they're talking about. You know who does? Dan Garner.

Dan Garner knows everything about the immune system. Dude, I'm super stoked on this because when I got my total physiological health score and you gave me a 68 out of 100, it was hard.

Because then I knew for the first time in my life that I felt immunocompromised. I felt like before you gave me a 68 and I got a D plus on my health score, that someone could have coughed COVID right into my nose and I would have been like, get at me.

Come at me, COVID. Come at me right now. And I would have just brushed it off, no big deal. Next thing I know, 68 out of 100, now I'm wearing a mask all around town like.

Oh my God. What is the immune system? Like tell me what actually goes on in our immune system.

This like giant concept of the immune system. Exactly, so it is giant. This is probably gonna be the most complex topic we ever tackle on this podcast.

So we'll revisit certain concepts as the episodes continue to go on. But from like a super bird's eye view perspective, the immune system, first and foremost,

75% of the immune system lies within or around the gastrointestinal tract. So the health of your gut plays an enormous role towards the health of your immunity.

And immunity is really, I think, a way in which I've separated myself from everybody else, like in this industry, with my approach. And really, you know why like I'm on a podcast like this today, because a lot of people just simply repeat the same things over and over and over again.

But immune system, that is going to govern many factors as far as your fat loss goes, as far as stress management goes, as far as muscle building goes.

And the health of the body depends upon the health of the immune system. And the adaptability score that you are going to get in my coaching program, like Anders received a D-plus in his total adaptability.

By the way, a D-plus is very good for people out there wondering like, I thought he was healthy. He has like a podcast, he talks about health. Turns out a D-plus, compared to many other people that have been in our program and seen what can happen,

D-plus is pretty good. Yeah, it's not bad, it's all right. He's like, I don't know about that. It's a D-plus.

Yeah, you gotta be a really- I probably have the highest GPA of immune system. I believe. You better be a real good salesman to sell me on D-plus, be honest.

Yeah. Yeah. But in any case. It's pretty good, though. A lot of people probably still are, they're thinking like, okay, immune system,

I get it, like I don't wanna be sick. Like, I don't wanna die from COVID. I don't wanna get a cold, I don't wanna get the flu. Like, I don't wanna have a disease. But they don't associate the immune system with training, and especially not with training results.

Like, they don't associate the immune system with putting on muscle mass, with being lean, et cetera. Like, what's the connection here? Sure, so we've talked about a lot in podcasts before about the health, the body is going to adapt to the degree that it is healthy.

That's something I am 100% certain. I know that that is something that is one of the most important factors towards driving world-class performance.

The health of the immune system determines the health of the body. The health of the body determines the degree of adaptability from your training. And the degree of adaptability from your training is determining the results that you can expect to receive from any pursuit that you're currently undertaking.

So when you're looking at what's driving stimulus and adaptation from training, you are looking at the immune system. And to kind of keep in theme with the past several episodes we've done with respect to blood chemistry, your immune system, now put super simply, is basically a function of what the white blood cells are doing in the body.

And with the white blood cells, you have five categories. You have neutrophils, lymphocytes, monocytes, eosinophils, and basophils.

Those are five white blood cell categories that you'll see in your blood chemistry. Your neutrophils are the most abundant, and they're like pit bulls.

They're not very smart. There's the most abundant immune cell in the body, and it will go around, and I call it like a pit bull because it'll kill certain things, but then also leave a lot of debris, leave a mess, leave some pro-inflammation.

They're not too intelligent. And that's the most abundant one. Your second is the lymphocytes. Now, lymphocytes, they'll be elevated typically in response to, say, viral infections.

And we'll probably talk more about lymphocytes as episodes go on because they play a huge role in inflammation. So that's where a lot of that conversation will center around.

The monocytes, on the other hand, these are known as early macrophages. Macrophage just means big phage, big eating. These things actually eat certain cells of our own tissue or bacteria in order to get rid of them.

So like when I said a neutrophil will kind of grab an issue in the body and shake it like a frickin' dog, and then that's what's gonna happen to it, a macrophage is more intelligent in its approach to where it will literally consume something.

So let's say a bacteria is trapped in a cell of your body, a bacteria infection. A macrophage will actually consume that entire cell.

It will eat your own body in order to destroy that bacteria. So that's what you're gonna see on a blood chemistry with respect to monocytes.

And then the last two are eosinophils and basophils. They are made in much less quantity. Both of them react to allergies, but eosinophils will be up in response to parasitic infections in the body.

So like super broad overview scope, you've got your neutrophils, which are the pitbulls, respond a lot to bacteria. Lymphocytes, a little bit smarter, connected to inflammation, but definitely connected as well to viral infections in the body.

And then you have your monocytes, which are the eaters of problems. And then we've got our eosinophils, connected to allergies and parasites.

And then our basophils, really just connected to allergies. So that's like your real overview. And I think that's important to care about because when you look at a basic blood chemistry

Now, you know as everybody here is listening to this if you've got a really high distribution of neutrophils Well, it's an indication of a bacterial infection because that's what neutrophils will be elevated for

So if somebody has a basic blood chemistry and you've got really high neutrophils Well, then it's probably a good idea to order a stool test to see what bacterial infectious state is currently happening Or if you're seeing a big elevation in lymphocytes, well, then you may have a viral issue currently in the body if eosinophils are just

Erratically up at the moment. You could have a parasite problem right now there's a lot of things that a blood chemistry can tell you that a lot of people aren't Looking deeper into because your white blood cell count could be normal

But if you've got a big distribution of neutrophils compared to everything else We know even though total white blood cell count is fine You've got a bacterial issue and we need to be looking into that because if we don't there's a root cause currently going unaddressed

That's impacting your ability to burn fat and build muscle period So as an example, like I had I had a couple of different opportunistic bacterial overgrowth, but my neutrophils were were very low And just like the both of the the percentage and the absolute amount

Like why would why would something like that happen then? So you can have that and you'll see different aspects in the literature on this if you have a neutrophil to lymphocyte ratio That's greater than three to one. It's associated with a bacterial infection

Or if you have a neutrophil to lymphocyte ratio of one to one it's associated Yeah, it's associated with both bacterial and viral

So it's one in the same you just fell into that ratio category that you're currently in So if that's why I said it from a simplistic perspective

Lymphocytes will be up in response to viruses, but the one-to-one ratio of neutrophils and lymphocytes is representative of both viral and viral and bacterial infection screwed

Yeah, so it's something that's just that's got to get looked into and it plays and this is kind of I'll actually dip into stress a little bit in this topic because this kind of follows that exact same pathway

And doug brought up his own labs, but I think anders is a there's probably a good example for the the immune stress connection um, he's already told you about his score and uh

This is one of the reasons that played into that little bit lower score despite his you know Doing tons of things correctly and coming to me very healthy. There's still just hidden stressors that need to be looked at so

Again, very big picture made a lot more simple. There's two branches to the immune system You have your th1 branch and your th2 branch

Now th1 and th2 don't stand for tony hawk one and tony hawk They stand for t helper one and t helper two

Your body will activate the th1 branch of the system in states of infection Because it is going to activate what I talked about previously macrophage

It's going to activate macrophages so that macrophages can eat this bacteria problem and get rid of it That is something that the th1 branch will stimulate

The th2 branch is only stimulated in response to extracellular things. So allergies or parasites Hyper simple you could think about th1 like intracellular

Bacterial problems and th2 like extracellular parasites or allergies things that don't actually fit inside of cells Now I and this is something i've come across in my career a million million times

And i've actually got a cool story about this if we've got time but your th1 branch will be stimulated in response to Get rid of infections now

Many people are fascinated with cortisol cortisol actually inhibits the th1 branch of the immune system and stimulates th2

Now something I probably should have mentioned is th1 and th2 are like a teeter-totter If you want to maximally support one, the other is suppressed You want to maximally support the other then the other is suppressed shrug family some very cool news coming out of walmart

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This is really important to care about because if you go to a lot of practitioners just make this huge mistake by not Understanding the immune system because if the body will suppress cortisol secretion

In an infectious state And it does that to maximize the th1 branch because cortisol stimulates th2 You stimulate th2 then you suppress th1

We need a lot of th1 in order to get rid of the bacterial infectious state But if you go to the average freaking practitioner who runs a salivary cortisol panel and believes in dumb things like adrenal fatigue Well, then they're just gonna look at your labs and say hey, you've got low cortisol

We have to bring up cortisol. That's what you need to do It's not you have low cortisol. Let's bring it up It's why is cortisol low to begin with because low cortisol is actually a protective mechanism of the body

To stimulate th1 as much as possible in a state of infection So if I was to raise cortisol in this person with a bacterial infection Then I would actually delay and prolong

Their infectious state and therefore delay and prolong the root cause of the problem And the reason I thought about anders for this podcast is because he had 7 million coffees a day

Before he started working with me and then we got we got lowered the coffee. I believe by like 50 percent anderson Am I right more than that more? Okay, so two-thirds

Okay, so anderson 20 ounces a day Right, and he also had an infectious state. He had a gut infection So his body was purposely going lower and the overall cortisol perspective

In order to support the th1 branch of the immune system because it was dealing with a gut infection I am getting rid of his gut infection

So therefore his natural energy is going up because his body doesn't need to suppress cortisol as much as it used to because he's getting Rid of the infection. So if he came to me and and that's why he had to overcompensate with more coffee

He was drinking tons of coffee and if I saw okay Let's just raise your cortisol to give you more energy Your gut infection would still be there and you would still be having a ton of coffee every day But now your gut infection is being eliminated and eliminated

So now you need 66 percent less coffee per day to have even more energy than you're used to So you're both a healthier person and a more energetic person and that is what's gonna freaking get you better results. So stress

Yeah, go ahead. Go ahead. No, I was gonna say that everything you just said Is 100 exactly what happened in the first 30 days of yeah, um all of it My sleeping the other thing that I started to notice um, and i'm not sure if it's 100 related but the

My sleep got significantly deeper um, yes when Like not only when I woke up did I need less coffee? but when I actually went to sleep it was like

Notice like when one of my kids would cry and I'd wake up I would just be like, holy crap I am coming out of like the the cave right now. Like I was just Knocked out. I have never slept this deep before those were like the two things that I immediately noticed like waking up I did I could literally go to like 10 30 these days where it was like without coffee where before I mean both these guys have traveled with me multiple times and it's like I am like I I was is like a

Lost person in the sahara looking for water like crawling to the coffee machine To get some energy rolling for the day Um, it happened like 30 days. It was the very first thing that I noticed like those those two things

I was like, whoa, they happened at the same time just Wow Things are absolutely changing For sure and for that and that's the thing too. A lot of people think this stuff takes forever It's if when you have a targeted when you have a targeted, uh protocol dealing with someone's true root cause issue

It doesn't take that long like my people routinely report. They feel better within two weeks that's because we were getting to the actual root cause of the problem because ander's cortisol wasn't low because he had some nonsense adrenal fatigue And his cortisol was low because his immune system wanted to stimulate a branch that the cortisol would oppose

So his immune system was intentionally lowering cortisol to support th1 activity to deal with the bacteria But he was overcompensating by drinking way too much coffee and also sleeping poorly two things that elevate cortisol

Which essentially just prolonging and delaying his body's ability to get rid of that bacteria infection if that goes on for too long then that infection is going to lead to two and then two might lead to three or four and then four and then well

That's when people start calling me like hey, you know, something's wrong I don't know freaking what it is and now that gone and you're sleeping better

Which means you're sleeping better is going to improve your immune system and your infectious state gone is going to improve your immune system So you're going to get better freaking results from any program you do now, you know

At the very end of their training when they're about to peak They you know, their immune systems are are tanked Do you think that if they like would pay more attention to like, you know, the details that they could avoid that somewhat?

Yeah, so and I think that that's kind of it almost goes in right to what we're Right because bacteria are viral infections These things are managed by our th1 branch of the immune system

But if you're a back to you if you're a bacteria in training camp, I almost said that If you're an athlete in training camp

Then you are making tons of cortisol every single day and then the sooner and sooner and sooner you get to that event The more nervousness and anxiety you have so you're making cortisol

So you're stimulating the th2 branch and completely inhibiting the th1 branch, which is protecting you from getting sick before the event, right? So it becomes so recovery becomes important during training camp stress management becomes important and sleep quality becomes important

All of those things are independently important, but they are maximally important for immunity Which is going to allow you to survive training camp and then go kick-ass That'd be good time to use some of the breathing techniques. I would imagine

Absolutely One more time. We dig into the relationship between between coffee or caffeine specifically and and cortisol So one of the ways in which coffee or the way in which coffee

For sure Stimulates your ability to have more alertness and more energy as it creates glucocorticoid secretion from the adrenal glands So glucocorticoids are just a selection of hormones coming out of the adrenals cortisol being one of them

Cortisol is a hormone of energy. So we are get ticking in our caffeine creating An acute release in cortisol which then increases energy and alertness

So that's essentially how caffeine is giving us energy But with an enhancement in cortisol in an infectious state That's also going to decrease your th1 branch and therefore

Potentially prolong that infection and this kind of makes sense like even just think about this you guys When you're really sick, is there a natural decrease in energy?

There is a major natural decrease in energy. Why because it's suppressing cortisol It is suppressing cortisol to maximize the correct branch to get you over this one Your body is smarter than we give it credit for your body is saying hey sit in one frickin spot

Let me maximize immune function and then once we get rid of this problem I'll give you some more cortisol again to continue on with your day And that's when you wake up the next day and oh man, I'm feeling better. I've got more energy

Oh, that's just because the body has done its job and now you're back to homeostasis When you think about I don't know how

Anxiety on like maybe a low level or heightened levels of anxiety When Travis was talking about how athletes are peaking towards the like leading up to ramping up to competition is anxiety

Anxiety's effect on your physiology or on your immune system It's kind of like a low level every single day ramping up to some event that never Actually happens. How does anxiety play into the overall stress?

Side of this Am I my tracking that right? Yeah, because stress stress in any form is gonna take a hit on the immune system, but stress in any form So if it's psychological emotional physical

Environmental these is these are all gonna play into your body's you know What I call your total body stress load and if we're getting multiple of these in per day That's multiple insults to the immune system, which is slowly and slowly gonna whittle away at that immune system leading up to competition day

But anxiety, I mean, I don't know if you like there's a difference between nervousness and anxiety because nervousness is when you're just you something You care about something a lot, but you're prepared but you're prepared but you care about it so much that you're nervous

Whereas people who have anxiety normally they have anxiety because they're not prepared It's a different feeling than nervousness nervousness means you care Anxiety means you you're not sure if you're prepared for this thing and that's why you have this anxiety

So I really think the the antidote to anxiety is maximal preparation. That was deli helps I think there's like some like there's a study out there that would say that it's the

Interpretation is the key. So like if I get the everyone is gonna get butterflies, you know, every fighter every Athlete are you interpreting the butterflies as like excitement or do you interpret it as oh shit?

I'm nervous. So it's like that's a big part of that as well. I totally agree It's everybody's gonna get butterflies So what separates the good from the great as the great are allowed to get those butterflies to fly in formation

Sir, right. Yeah, you use those things exactly Hmm, so if you say you get in an argument with your with your brother or something like that So you have like this this psycho-emotional stress that's happening because you're in conflict with somebody like physiologically what's happening there?

And how does that affect your immune system? Well your immune system again it's good it's going to that cortisol decrease over time and and any kind of stress is going to lower your immunity over time and If you take if a lowered immune system is going to impact fat loss and it's going to impact muscle gain like for example

If you're if you're somebody who's chronically stressed Well, then you're going to have a disrupted immune function that disrupted immune function can lead to inflammation and that inflammation problem can definitely lead to problems with muscle building without a doubt like and this is kind of a really cool one too because there's something called il-6 or interleukin-6

It sounds fancy. It's not inter just means between cells Leukin refers to leukocytes, which is a white blood cell and six is the messenger code So just between white blood cell messenger and il-6 and it just shows kind of the complexity behind the immune system

Which is why I'm so fascinated and curious with it il-6 when secreted from a fat cell is a pro-inflammatory cytokine But when secreted from a muscle cell is an anti-inflammatory

Myokine, so it's it has dual roles and implement It has dual roles and inflammation and you actually see in the literature that chronically high elevated il-6 is Yeah negatively correlated with muscle

Whereas acute raises in il-6 are positively correlated with muscle So if you're chronically inflamed your muscle degrading, but if you're acutely deflamed you are anabolic and it's the difference Between il-6 being secreted from fatty tissue or being secreted from muscle tissue and mechanistically speaking

Il-6 has been demonstrated to recruit satellite cells and signal muscle repair So il-6 plays a huge role in your ability to adapt from exercise after the muscle damage that stimulated that

Adaptive response. So when you ask me questions like hey, what about anxiety? What about stress? What's happening mechanistically? It can go in many different directions and it kind of depends upon your goal because if you have anxiety every day

But your goal is to gain muscle Well, then il-6 is gonna is gonna ruin you at the end of the day But if you have a goal of fat loss and you're stressed every single day Well, then that chronic inflammation will make your fat loss a lot worse and that chronic inflammation can also lead to leptin resistance

Which is gonna make your fat loss worse as well so it can go in a lot of different directions and leptin is kind of a cool one to a lot of people know Leptin as a a metabolic stimulator. It's that way. It's like a

Regulates appetite and it also determines your basal metabolic rate to a large degree But what many people don't know is leptin is actually immune stimulating

So after a meal And this is kind of cool. It kind of ties back to the beginning of the podcast. I'm glad Uh, we're talking about this

I said at the beginning of the podcast that about 75 percent of our immune tissue is in and around the gastrointestinal system and the reason why it's there is because

The way in which we take in potential pathogens is via food If it's going to be something allergic

Well, then our immune system's got to be right there in the gastrointestinal tract ready to deal with that allergen right away So it doesn't kill us eventually Oh, and also if that food has say a fungus or a bacteria or something on it

The immune system's got to be right there right away to deal with that problem before it enters circulation That's why there's so much immune tissue in and around our gastrointestinal tract but

Leptin is secreted after meals to act as an appetite suppressant To signal that we don't need to eat much anymore because we have received sufficient food

Leptin also is immune stimulatory Which makes sense because when leptin is increased after a meal to suppress appetite It also means that food just came in and if food just came in then we have to activate the immune system

To make sure that there is nothing in that food that's possibly going to create a problem for us And people who are obese become leptin resistant and if you become leptin resistant Well, then you make a ton of leptin to try and overcome your resistance

But that leptin results in more immune activity and that more immune activity in the wrong body will result in more inflammation And it ends up being a terrible cycle that you've got to get yourself out of if you want to fix your health and body composition

You mentioned obesity and I think that oh go ahead doug if you got a follow-up there Yeah, I was gonna say it's purely the fact that you have a lot of body fat that somehow exactly what I was gonna ask Produces leptin resistance. Yeah

Correct. Yeah, so leptin is secreted from adipocytes or fat cells, uh put simply so leptin secreted from fat cells To try and tell the brain. Hey, we've got enough body fat storage

You need you need to stop eating at this point in time But as people become more and more obese and even just the way foods are designed high palatability with high salt high sugar high amount of fats

They override a lot of our regular appetite controlling Mechanisms to where our body keeps making a ton of leptin But then our brain eventually becomes leptin resistant because of the amount of leptin that's in the body from all of the fat cells

In a similar way to where our muscle cells become insulin resistant when there's way too much insulin around Our brain cells will become leptin resistant when there's way too much leptin around

The problem is that leptin even though it's being resisted from the brain from an appetite perspective It's not being resisted from the immune system The immune system is going to continue activating that immune activity and in an inflamed overweight person that ends up being a problem so that person at that point, you know, it's important to

Uh, really get them on an elimination diet get them back into a calorie deficit get them resistance training manage sleep manage Stress all the things, you know that, uh, you know, you would already do with that person

But mechanistically they're gonna stay in that inflammation immune cycle and that will keep them obese until you unlock that and kill it uh, another word that's like super buzz word of the last two years is um comorbidities and obviously

They being obese is very taxing to your body also having these gut bugs or bacterial infections or viral infections in your gut how does this whole thing kind of like

I guess play together like is is When you think about obesity Is just being overweight so bad or is it this combination of all of it and and your immune system is just operate like stressed out and itself that it can't fight all of the things like I

How how challenging is being overweight to your immune system Incredibly challenging the one because at being overweight you have endocrine

Imbalances your hormones are completely thrown off when you're overweight. You're also insulin resistant. You're also highly inflamed You're also leptin resistant

It's also more painful to do exercise because your joints hurt You may also have sleep apnea which impacts your sleep quality Um being overweight is also likely a psychological stressor because you don't really want to to live that way or be that way

It is an enormous combination of things but the way in which i've always uh coach Um, everybody who comes my way let alone overweight people

Is that a lot of people think you need to lose weight in order to be healthy But the reality is that if you get healthy it will be so much easier to lose weight So that's exactly what I was actually

Uh, yeah way of putting it of like how like the framework of obesity and that should just get healthy first By getting healthy the weight will has to come down

Yeah, dude, and that's that's the and that's actually kind of how I came across this philosophy I don't know if i've ever talked about this. It's because i'm i'm a i'm a functional medicine practitioner So there would be people who had come my way with just a migraine or just say bloating or just constipation

And then I would say do a protocol to fix their migraine and then they lose 10 pounds Or I do a protocol to fix their digestion and then this person lost 15 pounds and I was kind of like hey What's what like i'm not actually focusing on body composition, but i'm getting body composition results

As a byproduct of improving this person's health. Yeah So it was like this big aha moment where I was like man The we need to get healthy and then weight loss comes naturally because the body's homeostatic

Where it wants to be is at that healthy set point, but there is a current dysfunction and a root cause issue going unaddressed That's keeping the body out of the set point

It's keeping it dysfunctional, but when we reinstate function weight loss happens so much more naturally and that's when I kind of started combining because like In my earlier career and I was more of an amateur like I had fat loss protocols and and muscle building protocols and they worked

But they didn't work at a world-class level until I combined them with health promoting protocols And when I did health plus the body composition stuff it was game over that that's when my reputation started getting heard I I feel like that the the idea or like the framework of just feeding your lean body is is something that

It's like Oversimplified but it really is like the the easiest like let's just eat really well but feed the skinny person like when I look at somebody that's obese or even if they just have like

30 pounds to lose i'm like well inside you is like a normal skeleton With normal muscle and normal organs and normal all of this stuff But on the outside, there's all of this extra shit that you're carrying around and if you just feed

The the skinny person inside there you don't have to worry about The perfect number of calories like obviously there's there's a system to doing it, but just get you healthy and

I I guess in a way, how do we know like, um How do people find out

Outside is is there a way to really start to work on their gut health because that seems to be like you're obese You definitely have some sort of infection or viral infection going bacterial or viral infection going on in your gut which is also just hammering your immune system, is there any way that people can just

They may not be able to go take stool tests and go through this entire protocol that we have like how would somebody start? To go man, maybe I have like yes, i'm obese i'm guaranteed to have some sort of infection in my gut

Where where do we go to start getting healthy? So that's if you think you have a gut infection then I would recommend referring out That's really how I would open this. Yeah, because

It's not something you can really do part-time That's something I say a lot is like lab analysis and proper protocol design is not something you can do part-time So I would really recommend just seeking out a specialist

Um at that point because someone who with uh with a lot of theoretical knowledge, but also a proven track record of success They're going to help you more than anybody else is ever going to help you

And you don't want to you don't want to make the you know, make the wrong move like so let's just I'm, really glad you asked that so curcumin is one of the most popular supplements, right? Yeah curcumin is th2 stimulatory

So if you currently have a major gut infection your body's trying to maximize th1 But you're pumping way too much curcumin every single day Well, then you're maximizing th2 which is ultimately going to limit your ability to maximize th1

Whereas berberine for example is th1 stimulatory So berberine in this situation, you're looking at say anti-inflammatory compounds, right? Okay berberine curcumin. They're both great options But I but possibly it's i'm i've got some signs here that i've got a bacterial infection in my body

So I should probably stimulate th1 while I mitigate inflammation response So in that specific client berberine is the way more tailored and targeted supplement for that person because it's going to act as an antibacterial

Antimicrobial through activation of th1 but it in and of itself has anti-inflammatory properties So given curcumin, which is everyone just thinks that you can there's there's a list of supplements

So people just think you can give anybody at any time for whatever reason It's just not the case and that's a great example of hey Maybe talk to a specialist if you've got an infection because you might just screw this thing up totally

There's some studies that show that you know when people are about to do vigorous Vigorous exercises like long distance running or like mma fighters by simply supplementing with like Carbohydrates that it actually lowered. Um cortisol

Intensuated like the il6 and il1 So With something as simple as just taking carbohydrates

What are your thoughts on that? Yeah, of course that carbohydrates one of their prime mechanisms is they lower cortisol That's that's one of the reasons why they're good post-workout

They're they're good post-workout chemically and structurally because structurally they replenish glycogen, but chemically they lower cortisol So you're getting an animalism and anti-catabolism at the same time and with that protection of animalism and anti-catabolism

You are going to have a mitigated and managed immune response because you are getting help from an exogenous source That's contributing to the positive outcome of your current immune state. So yes

Carbohydrates can absolutely help in in that respect I've seen all the people who've said negative about carbohydrates after post-workout They were only looking at one like the old charles pollock. He would say you needed that to

Spike insulin or whatever, but there's more than one reason why you would want that then Yeah, I mean it's going to structurally for glycogen chemically for a reduction in cortisol which will also create a production of testosterone because the ratio is going to help uh,

Because cortisol and testosterone have an antagonistic relationship with one another Furthermore, one of the biggest things that happen during training is dehydration and it's in the name itself carbohydrate carbs actually

Draw carbs draw both water and electrolytes out of the small intestinal tract and deliver it to the muscle cell faster than if you have uh water and carbohydrates alone

That's why when you look at something like pedialyte it's given in hospitals to save people's lives who have Diarrhea that won't stop like some crazy infections

People are given pedialyte for maximum hydration in minimal time It includes sugar because it sugar is more effective at uptaking water and electrolytes and water and electrolytes alone so carbs for glycogen for insulin for

Hydration for the testosterone and cortisol ratio. There's a lot of reasons Yeah, it continues going on. So it's it's just a very wise thing to do

And I always look at everything as a cost benefit analysis And in in the case of post-workout carbohydrates the benefits outweigh the cost in almost all physiologic contexts So is there a rationale then there for for not eating carbs right away early in the morning?

Because it'll depress what is supposed to be a rise in cortisol in the morning So this is where it kind of gets strange again. There's a yeah, the the body is fascinating when you have carbs determines the degree of

Excitatory mechanisms in the body. So having more carbs at night time is actually more suppressive But carbs in the morning aren't as suppressive

The circadian rhythm nutrition is something that's slowly unfolding and it seems to be very cool In that carbs in the morning aren't nearly as inhibitory as they are later in the day

So carbs in the morning are still a okay, and we're still learning a lot more about that in the data Cool, so fruit loops are cool. I can I can still eat fruit loops in the morning right when I get out of bed Okay, any other questions here

You're like wow, he didn't hear anything i've been saying on any of these shows Um, how so

The kind of the third bullet that we wanted to get to is on building muscle uh, and I think we laid out in the very first show that we were talking about how Um, actually building muscle is an immune response which is something I have been lifting weights for

25 years now and never heard somebody present um How does how does the immune system, uh, really get into being the reason for hypertrophy

Sure. So when you are driving hypertrophy, you're really looking at mechanical tension metabolic stress or muscle damage Those are the three main pathways you want to hit mechanical tension metabolic stress or muscle damage damage being actually damaging the protein structure forcing an adaptive response metabolic stress being pumping the muscle up just put very simply

And mechanical tension stretching the heck out of the muscle under a heavy load does forces a chemical secretion response inducing an adaptive response all three of those are stimulated by immune function all three of those create localized inflammation via like the IL-6 pathway that I just talked about, which stimulates the adaptive response. So we have the stimulation of hypertrophy coming from mechanical tension, metabolic stress, or muscular damage.

Those are acute inflammation. When the adaptive response is also mediated by the immune system, because the cell signalers and messengers that are telling the body, hey, bring amino acids over here, bring electrolytes over here, bring hydration over here, bring glycogen over here.

Those are all immune system signalers as well. So in the gym, we create localized, purposeful inflammation, so that outside of the gym, we have localized, purposeful adaptation. The immune system is what governs both of these things. It is the the ultimate determiner on whether or not you are going to maximally stimulate or inhibit training. Actually, there's a relationship between chronic and acute inflammation, like I talked about a bit with the IL-6, that chronic inflammation is associated with suppressing muscle growth, whereas acute inflammation is associated with driving muscle growth.

And it's basically creating a signal in the noise, because if you have normal levels of inflammation throughout the day, when you're in the gym, your high level of inflammation creates a large spike relative to your normal inflammation level. But if you have high inflammation all day every day, well, then your spike gets lost in the noise of the other existing inflammation, and therefore a stimulus is never really seen. So chronically high individuals, it's known as anabolic resistance. It's something that people can check out. Your body is resistant to the anabolic adaptation of exercise, because there is simply too much inflammation present that the acute stimulus got lost in the chronic noise. Since chronic inflammation, as well as acute inflammation, and all of the adaptive processes, are

100% mediated by the immune system, we need to have a healthy immune system to have a healthy stimulus. And if we have a healthy stimulus, we'll have a healthy adaptive response. And what people don't understand is that this chronic inflammation can have nothing to do with your training.

It can come from chronic stress. It can come from chronic emotional trauma. It can also come from a gut bacterial infection or a gut parasitic infection. It can come from so many different things. And that's why I like to look everywhere with my clients to identify, okay, where is there the hiccup in immune function so I can eliminate it at the root causal level so that this person's stimulus and adaptive processes can function optimally rather than just average. And that's what's going to take them past their current plateau.

Dude, I feel like I knew so much about lifting weights and like eating well, and now I know nothing. Like it's it's not even like a like I feel like I still know a lot about getting people really healthy and getting them great results, but like to actually really get it, you got to go do the tests. Like we've I feel like we've all along the way met somebody that's like in the gym, they're trying to eat really well, or they've been in the gym their whole life. And they're like chronically have low testosterone, or they like, chronically are like getting results, but you just look at them and there's just something wrong. And you're like, what, like, you kind of do all the pieces, but for some reason, none of it seems to be coming together and like a picture of any sort. And it comes down to their immune system. It's so weird to me. Like, I really like never understood that those two things correlated to each other at all.

For sure. And I mean, just to kind of add some light onto that. Some people just say, Oh, yeah, it's my genetics. I'm just not a muscle builder. It's just my genetics. I just hold body fat. Really? When was the last time you did lab work? And it's almost never. It's like, Okay, so why did you count yourself out? Because I'm not counting you out. You need to do your lab work, you need to figure out what's currently holding back your ability to maximally adapt, and then take action on it. Because so very 1% of people probably do regular lab work, let alone the the amount of lab work that I do on my clientele to get the results that I get. So it's just those those two questions, I think really shed a lot of light. Stop stop blaming yourself until you get all your lab work done. You don't know if it's your genetics or not.

Yeah, I feel like you went through this like massive popularity, like, I don't know, three years ago, four years, something like that, like, gut health was like this huge thing. And now we don't hear like anything about it. But it everything that I'm learning from you and through our clients, and when we go and do everyone has this thing. Not everyone, but everyone's got something going on, because they've just accumulated over the years. And then all of a sudden, you become like, a professional and you have kids and your sleep goes to crap. Like, I would love to know like your even your labs after having a baby in the last, how old is she now? Like three months, four months, three and a half months. I would love to see the difference between what your labs looked like four months ago and today to know what happened, like what happens to somebody when they have a kid like this, the amount of stress that builds up in your life that you just assume is normal life. Like, sometimes I think about like, healthy people are like, way back in the day before we had all these stressors in life. It's like, you know, much time, like humans, especially dudes just like spent walking with their bros hunting food. Like, that's like all they did. They just walked and tried to find some some poor deer struggling to hang out, then they go eat. Like that's, now we have all this other crap. And it's like, that stress is so brutal on your body. And like, now that I see labs, and now that I see results, and I see you break it and diagnose them and let you're not diagnosed, but break them down. Like, I feel like I I'm exposed to a world that is like, it's, I know, people should lift weights, I know, people should eat well, I know, you should get your vegetables. But now I'm looking at it and going, holy crap, we also have to have like a really big conversation about so much other stuff that's going on that like, yeah, you might have all that right. But check this out. This is sure, like a really important piece of this puzzle that you didn't even know existed.

No, and I mean, I got a story. I'll tell a kind of a quick cool story here. Well, I'll begin it with asking you guys a question. How many people wish they had more energy every day?

Yeah, totally. Pretty, pretty much everybody, right? Okay. And, and what we learned in this podcast, is that if we have an infectious state, we will suppress cortisol in order to deal with the infectious state. Cortisol is a hormone of energy. Many people are walking around with asymptomatic infectious states, which is suppressing cortisol and therefore lowering their energy on a day to day basis. So if somebody simply has low energy, that could absolutely be a symptom of a gut health disturbance. The symptom is energy. The symptom doesn't have to be loose stools and massive bloating. The symptom can be low energy because you're currently in an asymptomatic infectious state that the

Th1 branch of the immune system is trying to work on to eliminate that bacteria. So this actually, and this is where I'm going to tie into the story. I had a girl come to me once, and she had chronically low cortisol levels and very, very low energy. And she had worked with a bunch of people, the same old story. She worked with a bunch of people before me, everyone wanted to give her a bunch of herbs to stimulate her cortisol and give her a bunch of these energy teas and like nonsense, right? B vitamin, nonsense stuff just to try and get her energy up.

And all I did was give her Th1 supporting compounds. And then she came back 60 days later, and her cortisol curve completely regulated herself itself. I gave her zero supplements for adrenal glands and zero supplements for her cortisol. And yet her cortisol curve and for those who aren't familiar, it's the measurement of cortisol throughout the sleep wake cycle, it completely corrected itself. Because cortisol wasn't the problem cortisol was being suppressed due to the Th1 branch of the immune system's inability to properly dispose, dispose of an infectious state in her body. So I gave her immune supporting immune supporting protocols specific to the Th1 branch, which then allowed cortisol to come back up to its natural levels, because the infectious state had been eradicated. So that's just something I think is a cool kind of send home story for everybody that I think a lot of people can relate to with low energy, and stop just blaming everything on the adrenals.

And I can actually in a this weekend, I had to wake up Saturday morning at like 530. So I could go write a presentation. And I drank my old amount of coffee because I got five and a half hours of sleep the night before between waking up and doing it. And the very first thing I thought was, holy shit, this is how I used to live my life three months ago. Like, yeah, it was an absolute disaster. I literally had the exact same amount of coffee that I used to have. It was like, I was foggy all day. I kept like complaining, which is something I try very hard to never do. Because I know my wife has like, like real being up in the middle of the night all the time with a with a seven month old, like, I try not to, I'm like, I just feel like dog shit today. And all I could think was, this is how I operated for like, multiple years. Every single day just felt like this. And it's a massive difference.

Once you get that stuff. I haven't even redone the labs. But I know I can tell the difference. Day one was Saturday. It's like, this is how you used to live today is how you normally live. You don't need the caffeine. Your body just like handles it for you. You don't need all the extra crap body just handles it for you.

Right? Yeah, you eliminate problems at the root causal level and allow physiology to take it from there. Physiology knows what to do. You just have to get rid of certain dysfunctions that are offsetting its normal function. And once you get rid of that physiology will take the ball from there. Biology is incredibly intelligent. And we just got to go there. But there are certain dysfunctions because we add all kinds of crap on top of our life in the form of stress, bad diets, or traveling and getting an infection, all those kinds of things. So we got to look under the hood, just like you would in your car once a year, you got to look under the hood of the vehicle, your body once a year and make sure there's no dysfunctions. And then once you get rid of those dysfunctions, you're back to normal function. And I think it's cool that that in this podcast, you were actually a perfect case study of this, Anders, of impacting immunity and how that can have a huge impact on your energy.

When people think about energy, they want to take nootropics, they want to have coffee, they want pre-workouts. Some people will all like, hey, maybe if I get a great sleep, you know, like that, you'll hear a lot of these things like stimulants, like obviously, you know, take them or leave them. But people will say like good things about like sleep and stress management, these will definitely help. But how many people have you talked to who have referred the immune system with respect to restoring daily energy? None. And yet, it's of primary importance.

And I think a lot of people stay away from the immune system. And I don't blame them. It's ridiculously complex. And it's an immune system, right? Like if I wanted to cut out your gastrointestinal system, I could. If I wanted to cut out your nervous system, I'd just be cutting out your brain, your spine and the periphery and we would get it out there, the thyroid system, all those things that can be cut out. You can't cut out the immune system. It's on every single cell of the body working 24 seven. So if you wanted to remove one's immune system, you can't.

So to gain knowledge on it becomes very complex, because you're simply learning about the chemical signalers that every organ is secreting. And if it's doing something for one organ at one time, it might be doing something for another organ at a different time with opposing, you have to, you're basically researching chemical signalers and messengers, and their relationships from every organ. So it becomes extremely complicated. But then once once you got it, it's like, it's like the light came down from the heavens. And you're like, wait, this, this is going to be so helpful and help people. And it is, I feel like if people understood this too, we could eliminate so many of these like ridiculous thoughts about strength training.

Like when I think about like, it's like, am I over training? And you go, no, the problem is your frickin immune system is so whacked out. You're fighting bacterial infections, you sleep like shit, you're chugging coffee, you actually are like eating in a caloric deficit. So there's zero energy left over. And you think doing an extra set of back squats is the problem?

Think that like, oh, those lateral raises you threw in at the end are really the problem. No, dude, freaking go to sleep. Figure out how to be healthy, like get some lab work done. So you can just you can actually like move the ball forward in your overall health. And then you won't have to worry about like, oh, I did 25 working sets today. And science says 20 is optimal.

So am I over training? No, you're not. You're not at all. You're not even close. Like you're it's it's it's like a mute point. There's no reason to even talk about it. Because there's so many other things that people should be worried about. So far before, like, over training, like

I can't even believe that I thought I ever got there. The problem was, I wasn't sleeping for 10 or six years while owning a gym and trying to compete in CrossFit and trying to go do all the stuff like, why don't you just get healthy first and a lot of other problems on reaching your physical potential become a lot easier. For sure. Yeah, I mean, Travis, you've probably come across a million people who whose stimulus is just fine. It's just their adaptation is what they need the most work on. Right? Yeah, I had a girl Saturday. She was she's beating herself into the ground and her face is dripping. And she's like, you know, what should I do? Should I go do a lot more? I'm like, how does that make any sense? What you said? You're a wreck. Can't keep your eyes open.

You're asking me what extra should you do to get you out of this? Yeah. No logic whatsoever. Yeah. Yeah. That's crazy. Go to bed. Get out of here. Yeah. Eat, do something but don't do more.

Your homeostasis is wrecked. Yeah, we're all on this one side. That's it. Yeah. Dan Garner, tell the people where can they find you? You can find me at Dan Garner nutrition on

Instagram. There is you actually really should go do that. Not only does he crush it on the show, but he crushes on the Instagram to the new study you put up. I'm gonna we're gonna have like a

Dan Garner science, like most exciting science study that he's read of the day. The one on negativity. If you have not read that negativity is killing you like literally it's killing you.

You got to go over to Dan Garner's Dan Garner nutrition and learn all the all the new studies that are super cool coming out. Mashalead.com you can go to Instagram Mashalead performance or Twitter where I really prefer at Mashalead. If you want to get slaughtered by Travis Mash.

Dude, you got a new project coming out too. We're gonna talk about kid weightlifting. I want to hear about all this too. It's been going well. Yeah. I love it. Doug Larson.

On Instagram, Doug C. Larson. I'm Anders Varner at Anders Varner. We are barbell shrug to barbell underscore shrug. Get over to dieseldadmentorship.com where all the busy dads are getting strong, lean and athletic and make sure you get to your local Walmart. 2,200 stores nationwide. If you don't find my face on a box in the performance nutrition section next to the pharmacy, well you're in the whack Walmart. You need to go to the super cool Walmart next door because we're in over half of them nationwide. Friends, we'll see you guys next week.